Skelegen’s technology utilizes the Notch Signaling pathway ligand, Jagged1, which potently induces osteoblast differentiation and bone mineral production.  Jagged1 is not part of the BMP family and is not a soluble growth factor.  Instead it produces its effects as a surface bound cell-to-cell signaling molecule.  Jagged1 must be adsorbed to a surface to induce a functional signal; ligand that is free-in-solution or that diffuses from the implant location is inactive.  This greatly enhanced safety and performance feature does not depend on the design or manufacture of the device; it is a fundamental aspect of the biology.  Jagged1 can likely be paired with any commercially available scaffold, and has been tested with several biomaterials.