Skelegen’s technology utilizes the Notch Signaling pathway ligand, Jagged1, which potently induces osteoblast differentiation and bone mineral production. Jagged1 is not part of the BMP family and is not a soluble growth factor. Instead it produces its effects as a surface bound cell-to-cell signaling molecule. Jagged1 must be adsorbed to a surface to induce a functional signal; ligand that is free-in-solution or that diffuses from the implant location is inactive. This greatly enhanced safety and performance feature does not depend on the design or manufacture of the device; it is a fundamental aspect of the biology. Jagged1 can likely be paired with any commercially available scaffold, and has been tested with several biomaterials.